Who will respond to Vidaza?

[Birgitta-A]

Hi all,
Here is a quite difficult abstract about prediction of the responsiveness to azacitidine in high-risk MDS.

The important info is that the researcher soner or later will be able to know which patients that could be treated with Vidaza. We know that more than 50% will respond but the other patients only loose time and should try other drugs.
http://www.pnas.org/content/early/2009/09/09/0907109106.abstract
Kind regards
birgitta-A

[Neil Cuadra]

That's good news. If they can put this into practice, it seems that a test of the (PI-PL)Cbeta1 gene (PI-PL stands for phosphoinositide-phospholipase) could predict if a patient is more or less likely to respond to Vidaza. Presumably, that information could sway decisions about when to use Vidaza.