akita
Sun Dec 12, 2010, 03:10 PM
http://ash.confex.com/ash/2010/webprogram/Paper26539.html
3444 Prognostic Impact of Posttransplantation Serum Ferritin In Allogeneic Stem Cell Transplantation for Leukemia or Myelodysplastic Syndrome
This Japanese study evaluated the impact of the post-transplantation iron overload in 107 patients after allogeneic SZT."
There were included only people in the study who survived 1 year or longer.
The patients formed two groups with pretransplantation Ferritin < 1000 ng/ml - low, and >= 1000 ng/ml - high.
"There was no significant difference between the low and high pretransplantation ferritin groups with respect to 5-year overall survival"
"Patients receiving more than 6 units of RBC (after SZT, akita) had significantly higher serum ferritin levels from 1 to 3 years after SCT. Patients with chronic graft-versus-host disease (cGVHD) showed significantly higher serum ferritin levels from 2 to 4 years after SCT compared to patients without chronic GVHD."
A high ferritin after SCT was independently associated with worse 5-year OS and also with worse 5-year desease-free survival by multivariate analysis
Citation: "These results might help to decide which patients should be treated with iron chelating therapy after SCT."
3444 Prognostic Impact of Posttransplantation Serum Ferritin In Allogeneic Stem Cell Transplantation for Leukemia or Myelodysplastic Syndrome
This Japanese study evaluated the impact of the post-transplantation iron overload in 107 patients after allogeneic SZT."
There were included only people in the study who survived 1 year or longer.
The patients formed two groups with pretransplantation Ferritin < 1000 ng/ml - low, and >= 1000 ng/ml - high.
"There was no significant difference between the low and high pretransplantation ferritin groups with respect to 5-year overall survival"
"Patients receiving more than 6 units of RBC (after SZT, akita) had significantly higher serum ferritin levels from 1 to 3 years after SCT. Patients with chronic graft-versus-host disease (cGVHD) showed significantly higher serum ferritin levels from 2 to 4 years after SCT compared to patients without chronic GVHD."
A high ferritin after SCT was independently associated with worse 5-year OS and also with worse 5-year desease-free survival by multivariate analysis
Citation: "These results might help to decide which patients should be treated with iron chelating therapy after SCT."