Zolinza (vorinostat) can prevent GVHD

[Birgitta-A]

Hi All,
The histone deacetylase inhibitor Zolinza (vorinostat) can prevent GVHD in many patients: https://ash.confex.com/ash/2012/webprogram/Paper47682.html
Kind regards
Birgitta-A

[Neil Cuadra]

They call it a "proof of concept first-in-human phase I/II clinical trial" but oral vorinostat certainly made a difference in the trial, with severe acute GVHD reduced from 19% to 4%, less severe aGVHD reduced from 42% to 22%, and mortality reduced from 19% to 13% when comparing the study control group to the vorinostat group.

Despite the small scope of the trial, this is very promising. I wonder if vorinostat would make a difference after the fact for patients with GVHD or if its only target is preventing GVHD.