Hepatitis A causing SAA?

[Lucky]

Hi all,

Is there a chance of Hepatitis A to cause SAA? I know somebody who had Hepatitis A and after a year, he developed SAA. Has anybody experienced similar case, or do you know somebody with similar case?


Thanks a lot

[Neil Cuadra]

Yes, it could be hepatitis-associated aplastic anemia. Suspected causes of acquired aplastic anemia include ionizing radiation, chemotherapy, benzene-based compounds, environmental toxins, and viruses like hepatitis.

Here are some articles than mention the connection:
A Marked Decrease in CD4-Positive Lymphocytes at the Onset of Hepatitis in a Patient With Hepatitis-Associated Aplastic Anemia. (http://www.ncbi.nlm.nih.gov/pubmed/22246160)

Etiology and survival of aplastic anemia: a study based on clinical investigation. (http://www.ncbi.nlm.nih.gov/pubmed/23143628)

Billy Kiesel, Texas Musician Overcomes Aplastic Anemia Acquired Through Bout with Hepatitis (http://www.aamds.org/node/1600)

[Lucky]

Yes, it could be hepatitis-associated aplastic anemia. Suspected causes of acquired aplastic anemia include ionizing radiation, chemotherapy, benzene-based compounds, environmental toxins, and viruses like hepatitis.

Here are some articles than mention the connection:
A Marked Decrease in CD4-Positive Lymphocytes at the Onset of Hepatitis in a Patient With Hepatitis-Associated Aplastic Anemia. (http://www.ncbi.nlm.nih.gov/pubmed/22246160)

Etiology and survival of aplastic anemia: a study based on clinical investigation. (http://www.ncbi.nlm.nih.gov/pubmed/23143628)

Billy Kiesel, Texas Musician Overcomes Aplastic Anemia Acquired Through Bout with Hepatitis (http://www.aamds.org/node/1600)


Thank You! So, as I understand, there is no particular treatment for AA when it is caused by hepatitis viruses? I went through the links you shared and patients whose AA was coming from hepatitis got ATG/Cyclo treatment? which is a general treatment for AA...

[Neil Cuadra]

Yes, it's generally true that the specific cause of aplastic anemia, in the cases where it's known at all, doesn't affect the treatment choice.