bailie
Sat May 14, 2016, 05:33 PM
Does anyone have any experience with "donor cell leukemia" (DCL)? It is very rare. It is relapse that affects the donor cells and not a person's host cells. I think this is what I have experienced and will discuss with transplant doctor next week. The reasons I believe I have it is that my chimerism has been at 100 percent almost the entire time after transplant. The other reason is that when I relapsed (at Day about +210) none of my previous mutations were present. My post-transplant diagnosis is AML+Philadelphia chromosome (9;22). The doctors can't understand how/why that happened.
In one European study with 91 centers and 10,489 patients participating there were only 14 cases of DCL.
In one European study with 91 centers and 10,489 patients participating there were only 14 cases of DCL.