Arthritis drug for GVHD

[Marlene]

An investigational drug in clinical trials for rheumatoid arthritis prevents a common, life-threatening side effect of stem cell transplants, new research shows.

https://www.sciencedaily.com/releases/2018/04/180424184126.htm

[Neil Cuadra]

It's always interesting when a drug for one disease is found to be useful for other diseases.

They aren't sure how this JAK inhibitors (baricitinib) helps with GVHD, but the article shares one theory: that it keeps donor T cells circulating in the bloodstream and away from vital organs.

[Marlene]

If memory serves me correctly, Solaris, now used for PNH, was also being developed for RA but failed to treat it. It was a unexpected breakthrough for the treatment of PNH though.