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View Full Version : ASH 2010 Iron Overload Accelerates Development of Leukaemia - Mouse Model


akita
Sat Dec 11, 2010, 04:21 PM
http://ash.confex.com/ash/2010/webprogram/Paper30623.html

122 Iron Overload Accelerates Development of Leukaemia: Evidence From a Mouse Model

Transfusion related iron overload is common in MDS and causes many problems.

Citation: "Clinical data have suggested iron also causes haematopoietic toxicity in MDS since iron chelation can lead to dramatic reduction in transfusion requirements and in large registry studies leukaemia-free survival is inversely related to serum ferritin."

These observations had previously not been supported by data. In a mouse model this study leads to the conclusion that" iron is mutagenic in haematopoietic cells and can promote progression of a pre-leukaemic state to frank AML."