Haplo for AML with FLT3
 

Hi, I am new here. My 18yr old son just had a haplo transplant for AML M2 with FLT3-ITD-TKD and NPM1 with normal cytogenetics. He did go into transplant in remission. He did not have a mini transplant. They did a full myeloablative regimen using Busulfan, Fludarabine and Cytoxan before transplant, plus 2 more doses of Cytoxan on day +3 and 4. His Dad was the donor as I had too many antibodies. They took marrow from my husband but had issues getting what they wanted. Due to a differing blood type and processing of the marrow, they ended up with 1/2 of the amount they were hoping to give my son. Add to that, the concentration of stem cells was low. They don't know if he will engraft. They are prepared to do a 2nd harvest should he have graft failure. Due to the FLT3 mutation, they want to put my son on Vidaza at some point to help reduce his risk of relapse.

We are taking it day by day.

AML Momma,

Just wanted to wish you and your son the best.

Thank you. Today is day +8, and probably his first day of truly feeling bad. His counts have just now bottomed out, WBC is 0.09 this morning. Platelets were 8, but he got a transfusion and is at 22 this morning. Mucousitis is in full swing, and nausea and vomiting have increased again as well. The first week following transplant was very uneventful. I was kind of surprised he went this long with no issues to speak of. Then bam. Everything at once. :(

It is so different for each person. I "hit the wall" at two days before transplant and was stymied for about 20 days. Just extremely tired. My tastes for food and water changed greatly during that period. Nothing tasted good and I really had trouble drinking my two liters of fluids each day. The only thing that I ended up with was basically tomato soup. I was always experimenting to find what would work to fit my appetite.

I had my first and only transfusion at about Day+8 when my platelets reached a low of eight. Like your son, I bounced back quickly and at about Day 12 my counts just took off in a positive direction as engraftment was occurring.