Please explain How ATG works
hi all, my 4 years daughter suffering from Aplastic Anemia since April 2010. We have taken the ATG on December 2010. my confusion is how ATG treat AA. On day 1 when ATG start her lymphocytes goes around just 11% and nutrophils increase 44%. but as day pass lymphocytes grow back now around 95%. Cyclosporine is continuing right now.
so how ATG works. My confusion is before ATG lymphocytes are 95% and after ATG it also 95%. so what is the role of ATG? |
how ATG works.... I think
In very layman terms, I think the ATG enters the system and the rogue T cell/s bands his/her army to attack this and leave your bone marrow alone, then the cyclosporine jumps in and suppresses your immune system thus rendering the rouge Tcell/s without the troops i.e. army is squished. (this is why we become vulnerable to bugs). ATG then leaves the system by the usual method, (toileting etc) and the cyclosporine keeps the big army suppressed while your bone marrow (stem cells) recovers and starts producing your own blood stuff.
Hopefully then you slowly reduce the cyclosporine and either go into full remission on partial. Not sure what stops the rogue T cells from returning...maybe someone a bit more knowlegeable can help with that one? |
Hi pvinod,
I think that you should bring up your daughter's high lymphocyte count with her doctor. There may be something else going on that is not associated with Aplastic Anemia or ATG. It may be the sign of another infection or illness. To give you a feel for lymphocyte percentages... My lab has a normal percentage (for adults) as 26-46%. Pre-ATG, my lymphocyte % was high (up to 67%). During ATG, it dropped to 7%. A week later, it was back in the normal range and has stayed there except when I am sick. This is despite being on Cyclosporine. Be persistant with the doctors to see what else may be going on! Her situation sounds unusual. |
pvinod,
Hopeful has experience with this, so I second her recommendation that you be persistent with her doctors. I did find this on the AA&MDS website: Quote:
So it seems it is not unusual for the lymphocyte count to be high, but the 95% you cite does sound very high indeed. Good luck to you and your daughter. Greg |
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