Preventing relapse after SCT in high risk MDS??
 

I understand some centers are using SC Vidaza to prevent relapse after SCT in high risk patients and there is currently a study with oral Vidaza.

Does anyone know of publications on these options or if there are any other drugs being studied post transplant?

Wife of Diver Down

I will send studies when I get home, but the three strategies my doctor spoke of last week wetter 1) donor lymphocyte infusion 2) vidaza and 3) reduction in immune suppressants. They have been using vidaza for about 2 years with high risk patients, in some cases before any relapse.

I had post-BMT Vidaza for 10 months, 5-day cycles subcutaneous injections, intended to help prevent relapse. So far, so good (knock wood). My transplant was at Johns Hopkins 11/30/2010. I was supposed to do 12 months but they thought it might be exacerbating GvHD so stopped at 10. I had no immunosuppressants (had post transplant cytoxan instead).

Here are a couple of articles about the use of Vidaza and/or DLI for higher risk patients:

http://www.ncbi.nlm.nih.gov/pubmed/20672358

http://www.mdsbeacon.com/news/2011/0...er-transplant/