AML and CML
Why aren't these diseases included the "Bone Marrow Failure Diseases"?
Good question! The forms of Leukemia (ALL, AML, CLL, and CML) also involve the bone marrow, and they share characteristics with AA, MDS, and PNH, with overlapping causes, symptoms, diagnostic tests, underlying biology, and some treatment approaches.
It's an arbitrary cutoff when they classify patients with multiple cytopenias, cell dysplasia, and 19% bone marrow blasts as MDS-RAEB-2 and patients with multiple cytopenias, cell dysplasia, and 20% bone marrow blasts as AML.
On the flip side, there are medical differences between these groups of diseases:
Just as the AA&MDSIF's name doesn't mention PNH, but they're just as devoted to helping PNH patients as AA and MDS patients, we want to serve people with pure red cell aplasia (PRCA), people with undiagnosed low blood counts, and other conditions that sometimes overlap, such as myelofibrosis. We've focused on acquired diseases but occasionally hear from people with inherited anemias like Diamond-Blackfan anemia, thalassemia, and Fanconi anemia.
Bottom line: These forums are focused on a few diseases, but they are open to everyone they can help!
Thank you Neil. It just seems like MDS and CML or AML closely overlap. In my case I had MDS then had a SCT and relapsed to AML +Philadelphia chromosome. From my readings, it seems like AML is closely related to MDS. I realize this is not a "big deal" for the forum. I was mostly curious.
You said, .... "while leukemias usually involve blood cell proliferation". In my case, I have never had a blood cell proliferation with my AML diagnosis. All of my CBC counts are on the low end of normal or just below normal.
Of all of the forums, this one seems the best to me. Easy navigation with great participation by everyone.
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