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-   -   RUNX1 gene (http://forums.marrowforums.org/showthread.php?t=5870)

lacanada1 Tue Nov 14, 2017 05:32 PM

RUNX1 gene
 
Has anyone ever come across the RUNX1 gene? Testing for it, both in the blood and skin biopsy. My docs here in London seem interested in it and have done it to me recently and just curious if anyone has any insight?

Neil Cuadra Tue Nov 14, 2017 06:09 PM

lacanada1,

If you search for "RUNX1" on the search page you'll find a number of other threads that mention it.

Data Tue Nov 14, 2017 07:28 PM

Runx1
 
The following is from the web site:
http://www.genecards.org/cgi-bin/carddisp.pl?gene=RUNX1

RUNX1 is a transcription factor that forms a complex with the cofactor CBFB. This complex provides stability to the RUNX1 protein which is involved in the generation of hematopoietic stem cells and for their differentiation into myeloid and lymphoid lines. Loss of RUNX1 function has been shown to impair differentiation between myeloid and lymphoid lines often resulting in the development of leukemia.

Data

lisa3112 Wed Nov 15, 2017 04:16 AM

Hey, I had runx1 prior to my stem cell transplant. It predisposes you to getting forms of cancer apparently. They have a new test in Australia which can pick up very small traces of it in your cells. My doctor wanted to make sure it was gone post transplant. Hope that helps 😊


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