Marrowforums

Marrowforums (http://forums.marrowforums.org/index.php)
-   Drugs and Drug Treatments (http://forums.marrowforums.org/forumdisplay.php?f=12)
-   -   Vitamin D Receptor Agonists in the Treatment of Autoimmune Diseases (http://forums.marrowforums.org/showthread.php?t=2588)

Lbrown Sat Dec 17, 2011 09:51 AM

Vitamin D Receptor Agonists in the Treatment of Autoimmune Diseases
 
This is a good article about the use of VDR agonists to treat autoimmune disease: http://onlinelibrary.wiley.com/doi/1...bmr.07s217/pdf

The treatment I'm on uses olmesartan as the VDR agonist, and you limit your blood levels of vitamin D to reduce the level of the hormone 1,25D (short for 1,25(OH)2D3). It is replaced by olmesartan which binds into the VDR.

When I had my vitamin D measured, my serum vitamin D was low, but my 1,25D (the active metabolite) was high. It is not common to test for 1,25D, which is why very often people have low vitamin D and are considered vitamin D deficient. If they tested for the active metabolite it could show otherwise. The theory is that most people with AI disease seem to be D-deficient, but it is a result of and not the cause of the disease, and is dysregulated in AI disease.

Deb

Joseph Z. Mon Dec 11, 2017 07:22 PM

Immunostimulation to treat Aplastic Anemia
 
Hi Deb,

It's been years since you posted but I'm wondering how you progressed with Olmesartan as treatment for your condition. I just finished reading the original Marshall article, "Immunostimulation in the era of the metagenome." Found it fascinating, but it seems like research in this area may have stalled. Can't find much since publication date that appears relevant.

I'd appreciate any info. you could provide. I'm Severe AA, post ATG, and currently on Cyclosporine and Promacta. Two months out of treatment. ANC has gone up slightly but otherwise not showing much response.

Thanks,
Joe Starr


All times are GMT -4. The time now is 03:20 PM.

Powered by vBulletin® Version 3.6.7
Copyright ©2000 - 2019, Jelsoft Enterprises Ltd.
Forum sites may contain non-authoritative and unverified information.
Medical decisions should be made in consultation with qualified medical professionals.
Site contents exclusive of member posts Copyright 2006-2019 Marrowforums.org