AA and chemotherapy
I've been doing a lot of research with the connection of autoimmune diseases, specifically lupus, and AA. When doing this, I came across this interesting little tidbit on the Johns Hopkins website...
Quote:
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That's High Dose Cytoxan. Dr. Robert Brodsky headed up the clinical trial at Hopkins for Aplastic Anemia. They have used it for other autoimmune diseases with varied success. The latest was for a certain type of MS.
John did HiCy for his SAA in 2002. |
Marlene, thank you for giving it a name for me! I had never heard of doing that for AA. I was only given the option of ATG or bone marrow transplant (would have been unrelated donor, which at the time was considered to have a very iffy success rate) when I was dealing with my SAA. When we thought the ATG wasn't working, my dr. told me that if he could just get me to live 5 more years, my options of treatment wouldn't be quite as grim. Now, reading and talking with drs. today, I have to say that he was right. :)
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Angie, here's another thread on this same topic: http://forums.marrowforums.org/showthread.php?t=492
As Marlene says, high dose cyclophosphamide (aka high dose cytoxan) is the protocol developed by Dr. Robert Brodsky at Johns Hopkins. As far as I know, he is still the only one using it. From what I understand, it is not recommended for anyone who has had previous ATG treatment, as that tends to lower the success rate. If you want to contact Dr. Brodsky directly: http://www.hopkinsmedicine.org/hemat...brodsky_r.html |
Thank you, Lisa! :)
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