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-   -   Reduced Intensity Conditioning (RIC) vs Myeloablative (MA) (http://forums.marrowforums.org/showthread.php?t=5815)

Data Fri Sep 8, 2017 04:35 PM

Reduced Intensity Conditioning (RIC) vs Myeloablative (MA)
 
I was under the impression I was going to receive Reduced Intensity Conditioning (RIC) prior to my stem cell transplant. My doctor later told me that I had received Myeloablative (MA) conditioning. From the following does anyone know exactly which I got? I believe the Total Body Irradiation was a total of 5 Gray.

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Cytarabine will be given daily through your central venous catheter (IV) continuously for 5 total days. Cyclophosphamide (Cytoxan) willl be given once a day through your catheter (IV) over approximately 2 hours for two (2) consecutive days. Total Body Irradiation (TBI) will be administered once prior to your transplant.
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Thanks

Data

Neil Cuadra Fri Sep 8, 2017 06:27 PM

Data,

Having only one day of TBI seems to imply that it was RIC, not MA conditioning.

Compare the regimens in this chart from this article and you'll see typical differences. 5 Gray is more than the typical RIC dose, but well below the typical MA dose.

Can you match your treatment to one of the regimens shown?

Data Fri Sep 8, 2017 08:23 PM

Nice chart
 
Neil,
I couldn’t find an exact match in the chart but the Cyclophosphamide (Cy), Cytarabine (ARA-C), and TBI seemed to be used more often in the Myeloablative Regiments. The dosage for the TBI did seem low in my case but then I can’t remember for sure what the dose was. I don’t have any records that state what the dosage was. I do have the records that say it was going to be RIC and what drugs were given to me and for how long. The main reason I got to thinking is was myeloablative was the doctor had said it was on a couple of occasions but I don’t really trust him because he has changed what he said on several occasions.

Thanks again for your comments.

Data

DanL Sat Sep 9, 2017 05:05 PM

Data,

I reviewed several articles on RIC vs MA and it appears that your dosing levels of ARA-C and CY would be the determining factors. It kind of looks like your doctor split the difference a bit. There are a few studies out of Germany and MD Anderson that used cytarabine as part of RIC.

I did not see anything that matched your regimen exactly though.

Data Mon Sep 11, 2017 04:07 PM

Thanks
 
Dan,
Thanks for the input. Sorry I haven't replied earlier. We have been busy with Hurricane Irma down here in Florida. Think she is gone now. Good riddance to her and my two ex-wives. Ha Ha.

Datd

DaveAvl Mon Sep 11, 2017 04:18 PM

Quote:

Originally Posted by Data (Post 43071)
Good riddance to her and my two ex-wives.

Great - now I have images of them both riding bicycles in the tempest, a la The Wizard Of Oz :D

DanL Tue Sep 12, 2017 04:04 PM

Quote:

Originally Posted by Data (Post 43071)
Dan,
Thanks for the input. Sorry I haven't replied earlier. We have been busy with Hurricane Irma down here in Florida. Think she is gone now. Good riddance to her and my two ex-wives. Ha Ha.

Datd


Very glad to hear that you weathered the storm successfully. Hopefully not too much damage to go back to.

Data Tue Sep 12, 2017 06:31 PM

Thanks Dan
 
Dan,
We never evacuated. I said I would evacuate when it got to a Category 6 (Ha Ha). We only had really small tree limbs break. We lost power for about 8 hours. No Flooding. The refrigerator kept everything cold/frozen. We were very lucky! I feel for those less fortunate.

Thanks again

Data


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