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-   -   Arthritis drug for GVHD (http://forums.marrowforums.org/showthread.php?t=6044)

Marlene Wed Apr 25, 2018 02:01 PM

Arthritis drug for GVHD
 
An investigational drug in clinical trials for rheumatoid arthritis prevents a common, life-threatening side effect of stem cell transplants, new research shows.

https://www.sciencedaily.com/release...0424184126.htm

Neil Cuadra Wed Apr 25, 2018 03:31 PM

It's always interesting when a drug for one disease is found to be useful for other diseases.

They aren't sure how this JAK inhibitors (baricitinib) helps with GVHD, but the article shares one theory: that it keeps donor T cells circulating in the bloodstream and away from vital organs.

Marlene Thu Apr 26, 2018 10:13 AM

If memory serves me correctly, Solaris, now used for PNH, was also being developed for RA but failed to treat it. It was a unexpected breakthrough for the treatment of PNH though.


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