Hi tennisdolly,
You know some patients respond very well to Dacogen , other respond to Vidaza och some do not respond to any of the hypomethylating drugs but do very well with immunemodulators like Revlimid, Thalidomide or Pomalidomide (not approved). Some patients get histone deacetylase inhibitors (HDAC inhibitors) like Epival or Zolinza and get good results.
MDS is not one disease but many diseases and the only thing we really know about responseveness is that about 67% of the patients with isolated 5q- will respond to Revlimid.
Vidaza is supposed to give a little better results than Dacogen - more patients (between 50 and 60%) respond. Here is info about Dacogen:
http://www.mdsbeacon.com/news/2009/0...les-asco-2009/
I am afraid this won't help you but we can only hope that we soon will get better methods for choosing the best drug for every patient.
Kind regards
Birgitta-A