Thread: Dacogen for MDS
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Old Sat Jun 12, 2010, 02:24 PM
Birgitta-A Birgitta-A is offline
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Join Date: Oct 2007
Location: Stockholm, Sweden
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Drugs

Hi CRPA,
There is a kind of drugs that are called Histone Deacetylase inhibitors. Several of them are approved for other diseases like Epival (valproic acid) and Zolinza (vorinostat). Both have showed quite good results in MDS - one member of this forum had a very good response during many months when she was taking Epival.

In this study with Epival (valproic acid) they found a response rate of 42% in MDS with a normal blast count.
http://abstracts.hematologylibrary.o...act/106/11/789

In this study with Zolinza most patients had AML – 7 of 41 patients improved.
http://bloodjournal.hematologylibrar...act/111/3/1060

Both drugs are often combined with other drugs for better effect.
Kind regards
Birgitta-A
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