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Dacogen options
Hi Mike,
Your results with Dacogen have been an encouragement to many.
Has your blast % increased? Any chromosome abnormalities?
It would seem that trying to increase the Dacogen dosage via a 4 week cycle could be tried before going to the more aggressive in hospital chemo. I've had success in reducing the blast% by increasing the dosage of Dacogen.
I attended the AA/MDS patient conf in Chicago this past weekend where Dr Steven Gore of Johns Hopkins discussed adding other drugs to Vidaza or Dacogen to improve the response in patients with MDS. One drug is vorinostat (Zolinza is the trade name), also has been called SAHA. A paper will be presented at the end of the year with the results of a study in combination with Vidaza. A search of vorinostat for MDS will show some studies.
Keep up you positive attitude.
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Kirby71, RAEB2 dx 2/04, Thalidomide 30 mo, Revlimid 18 mo, No resp Vidaza
6/09 2nd Thalid use, Promacta, Lowdose Dacogen added 10/09 at 40% blasts. 5/11 BMB-blasts 8%.
2/11 2nd Revl restart=good resp, Platelets drop 6/11, 3rd Thalid,+Nplate+Dacogen. 7/12 Cnts stable for 10 mo.
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