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SSA/RO associated with idiopathic thrombocytopenic purpura
Thromb Haemost. 1994 Feb;71(2):184-7.
High-titer antinuclear antibodies, anti-SSA/Ro antibodies and anti-nuclear RNP antibodies in patients with idiopathic thrombocytopenic purpura.
Kurata Y, Miyagawa S, Kosugi S, Kashiwagi H, Honda S, Mizutani H, Tomiyama Y, Kanayama Y, Matsuzawa Y.
SourceDepartment of Blood Transfusion, Osaka University Hospital, Japan.
Abstract
The clinical significance of high-titer antinuclear antibodies (ANA) and autoantibodies to cellular antigens such as SSA/Ro and nuclear RNP (nRNP) antigens in idiopathic thrombocytopenic purpura (ITP) was examined in a prospective evaluation of 66 adult patients with chronic ITP. ANA were positive in 29 (44%) of 66 patients with chronic ITP. The titers of ANA were high (1:160 or higher) in 14 of 29 ANA-positive patients. Furthermore, 10 of 66 patients had precipitating antibodies to nuclear antigens; seven patients had anti-SSA/Ro antibodies and the other three had anti-nRNP antibodies. None of high-titer ANA- or precipitating antibody-positive patients developed systemic lupus erythematosus (SLE) throughout the follow-up period of 3 years. In addition, we investigated retrospectively precipitating antibodies in stocked sera from 8 patients. These patients had already precipitating antibodies average of 7.7 years before. None of 8 patients developed SLE or Sjogren's syndrome (SS). These data demonstrate that high-titer ANA and antibodies to SSA/Ro or nRNP antigens are often found in patients with ITP, and indicate that the detection of high-titer ANA or the existence of antibodies to SSA/Ro or nRNP antigens by itself is not enough to identify those patients with ITP who are at risk of developing SLE or SS.
PMID: 8191396 [PubMed - indexed for MEDLINE]
Publication Types, MeSH Terms, SubstancesPublication Types
Research Support, Non-U.S. Gov't
MeSH Terms
Adult
Aged
Antibodies, Antinuclear/blood*
Autoantigens
Chronic Disease
Female
Humans
Lupus Erythematosus, Systemic/etiology
Male
Middle Aged
Precipitin Tests
Purpura, Thrombocytopenic, Idiopathic/complications
Purpura, Thrombocytopenic, Idiopathic/immunology*
Sjogren's Syndrome/etiology
Time Factors
snRNP Core Proteins
Substances
Antibodies, Antinuclear
Autoantigens
SS-A antibodies
snRNP Core Proteins
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Nicole, mom to Evan (20); diagnosed SAA November 2007, hATG mid-November 2007, no response after 6 months, unrelated 9/10 BMT June 2008, no GVH, health completely restored thanks to our beloved donor Bryan from Tennessee.
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