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Hey Lisa!
Love the disclaimer! We might want to add: "No large or small animals were harmed in the making of this opinion, though the same cannot be said of brain cells."
I'll try to see if I can find anything on the Campath for AA trial; if I have luck, I'll post the link.
Near as I can tell from reading the Wikipedia entry Ki67 is a protein marker that's abundant when cells are reproducing rapidly and more scarce when they are reproducing slowly. So the presence of Ki67 along with the high CD4/CD8 ratio means, like you explained earlier, that the killer cells aren't just more common than the helper cells, but the killers are reproducing rapidly.
That could be totally off, but I think it's right.
Take care!
Greg
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Greg, 59, dx MDS RCMD Int-1 03/10, 8+ & Dup1(q21q31). NIH Campath 11/2010. Non-responder. Tiny telomeres. TERT mutation. Danazol at NIH 12/11. TX independent 7/12. Pancreatitis 4/15. 15% blasts 4/16. DX RAEB-2. Beginning Vidaza to prep for MUD STC. Check out my blog at www.greghankins.com
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