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MDS to AML
Hi Layla G
Hydrea was used in our case to lower WBC. At my wife's stage it's being used to simply slow it down rather than have a major impact. As mentioned in another thread, Hydrea is not necessary the drug of choice for AML. The advantage is that it is available in oral form and can easily be obtained from drug store. Cytarabine, in doing some reading seems better for AML but is not as effective as oral form, better in subcutaneous and much better with IV. This means that usually it has to be done in a hospital or clinic setting. Revlimid definitely lowers Plateletes for a period of time, about 3 or 4 weeks and then stablilizes. To use both Revlimid and Cytabarine at the same time seems like an error. Maybe someone else can comment on this
Where is your mom's WBC levels. BMB does give some discomfort but with enough local freezing is fairly straight forward. That is if you are not sure if this is AML.
The big risk with AML is the dysfunctional WBC or lower WBC and the risk of infection.
Hydrea can also lower platelets. It seems the big issue right now is to stabilize the infection and then reassess the chemo treatment.
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Wife 63, June 2010 MDS (refr anemia - excess blasts type-2) PLTs 11,000/μl with giant forms 2 TF/wk. Hgb kept at 80g/l with 1TF per 2 weeks. 9% blasts 2 cytogenic abnormalities del(5)(q22q35) + inv(20)(p11.23q11.21) 3 cycles Vidaza no effect. June 2011 to AML WBC to 67 blasts and Aur rods in blood.
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