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Hi David,
If it has been only one week since she received ATG, she is likely suffering from serum sickness. It is thought that this can occur up to 2 weeks after ATG is complete. So, hopefully she hasn't started the prednisone taper yet or you may want to talk to her doctor about her dosing. Itching, hives, and joint pain are symptoms of serum sickness.
I don't think the cyclosporine alone is the culprit here. 100 mg twice a day is a pretty low dose. Also, it takes at least a month or two for the cyclosporine to build up in your blood. They should be checking her cyclosporine trough as well as her creatinine and BUN readings to make sure her kidneys are handling all the different drugs though.
I hope your wife will see a response.
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58 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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