|
Good job on summarizing the article Greg. The article I posted earlier in News and Events speaks to the blood stem cells vs bone marrow cell for use in transplants.
They found bone marrow cells have higher graft failure but better GVHD outcome while the peripheral blood cell have a better graft rate but with a higher rate of GVHD.
Hopkins has been successful using HiCy for two days right after the transplant to prevent GVHD. So if you combine the above with a reduced conditioning regimes, you may end up with an optimal approach.
Reduced conditioning + blood stem cells for better engraftment, followed by two days of HiCy to minimize GVHD. It certainly is more complicated these days to figure out what path to take.
__________________
Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of July 2021 HGB 12.0, WBC 4.70/ANC 3.85, Plts 110K.
|