Dear Ziad
In the info about prescription for Vidaza the drug company writes:
2.3 Dosage Adjustment Based on Hematology Laboratory Values
For patients with baseline (start of treatment) WBC less than 3.0, Neutrophils less than 1.5, and platelets less than 75.0, adjust the dose as follows, based on nadir (lowest) counts for any given cycle:
Neutrophils less than 0.5 or Platelets less than 25.0 give 50% of the dose.
If a more than 25% increase above the lowest count is not seen by day 28, counts should be reassessed every 7 days.
That means that the dose should be reduced to 50% of the normal dose and if the counts not have started to increase after 28 days the next cycle should be delayed.
http://www.vidaza.com/pdf/PI_FINAL.pdf
Kind regards
Birgitta-A