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Bob,
We can wonder what could cause such a rapid change after 15 years but there may be no way the doctors can solve that mystery. What matters is that you get through this treatment.
This must be a tough setback to take, but like you I think hoping for and working toward the best outcome is an important way we help ourselves. Even though this is not an easy treatment regimen, it may finally be the year you finally beat this disease.
I wish you the best of luck and I hope you have Penn's best doctors on your team.
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