[Marlene]

Hi Chirley,

Current thinking in the Functional Medicine world is that the type of Folic Acid used is critical. The folic acid found in most vitamins and in fortified foods is not recommended for those with the mutation. Even those without the mutation should avoid this form of folic acid. For those with the mutation, the body cannot utilize it, it builds up leading to other problems like cancer. For those without the mutation, they may not be converting it for other reasons...they could be lacking in the co-factors needed for the conversion. Some co-factors are B12, B6, B2, zinc and magnesium.

So even though you cannot correct the mutation, knowing you have it can provide some insight in designing a proper protocol to ensure proper methylation.

I listened to a couple of podcast on this and it was interesting to learn this doctor's approach to correcting methylation and the balance is key. Over methylation can occur so you really need a tailored protocol. Over methylation is easily dealt with and is usually a result of supplementing too aggressively. Or, there are other genetic mutations in the methylation pathway that have not been identified yet. This doctor starts with getting B12 levels up before adding in the bio-available folate. Without B12, the folate won't get to where it's needed.

Raw, green leafy vegetables is the natural way to get your good folate. If you supplement, L-methylfolate, quatrefolic or 6S-5 forms are the ones to use.

Anyone who is using nutrition as part of their recovery or treatment for their bone marrow disease would benefit greatly by understanding the methylation process at a high level.