Hi Shriya,
You could look at this site of this forum about MDS.
http://www.marrowforums.org/mds.html. MDS is very complicated so it will take months before you will understand what is happening to your father-in-law.
1 Blast cells are immature blood cells and ringed sideroblasts are immature red blood cells containimg ring-shaped iron deposits.
2 One of the bone marrow biopsies/aspirations is not representative for his bone marrow – probably the first one.
3 Good that his karyotype is normal
! If your father-in-law has MDS-RAEB2 the drug most doctors try first is Vidaza. Revlimid (lenalidomide) is best for patients with the 5q chromosome aberration. Revlimid can help patients with normal chromosomes too – I am taking that drug and have other aberrations than 5q and hope it will help me.
As Chirley wrote it is very important to control copper level because copper deficit will give the same symtoms as MDS.
Then you have to follow his hemoglobin, white blood cells and platelets. Write your own report with all info.
Kind regards
Birgitta-A
74 yo, dx MDS Interm-1 2006, supportive therapy with transfusions, iron chelating drugs, drugs for low white blood cells until 2010. Positive results with Thalidomide + Prednisone during almost 3 years. Now trying Revlimid + prednisone.