chelation reference + experience
Iron Overload in Myelodysplastic Syndromes:
Diagnosis and Management
Alan F. List, MD Cancer Control January 2010, Vol. 17, No. 1 Supplement A bit technical but you can pick something up.
End organ damage happens after Ferritin of 2000. Us high risk folks have such a poor prognosis that it is controversial whether to use chelation agents. I also can't use Exjade. Since I have a PICC line in I chose for Desferal iv 2000 mg 5 days a week via infusor, after I did a trial run of 1000 mg iv 5 days a week for 1 month and my Ferritin dropped 100. Chelation doesn't usually start till after 20-30 units RBCs. I started when my Ferritin was 1428 after 24 units. Hope this helps.
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