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teke152,
The information Whizbang found is what came to my mind too. Is your wife just getting off post-transplant immunosuppressants? If so, the drugs may have been keeping the GVHD at bay, and with an awakening immune system your wife's GVHD symptoms have now shown up. I don't know if that's the explanation for your wife, but if it is then it's a balancing act for the doctors to find the right dosages. It's risky to keep the immune system suppressed longer than necessary, even if it helps keep GVHD suppressed too. You'll find a wide variety of drug-tapering stories in these forums.
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