[Shazza]

Is it usual to have conflicting bone marrow biopsies?

These are the findings from my 2:

May 2013
10% cellularity with all 3 haemopoietic cell lineages represented but reduced.
Granulopoiesis shows maturation to neutrophils.
Erythroid islands are dispersed.
Megakaryocytes are hypolobulated & dysplastic.
Reticulin is normal.
CD34 is negative.
p53 is negative.
CD117 is staining mast cells only.
CD61 confirms dysmegakaryopoiesis.
The megakaryocyte abnormalities raise the possibility of a hypoplastic myelodysplastic syndrome.

October 2013
10-15% cellularity with all 3 haemopoietic cell lineages represented & showing normal maturation.
Granulopoiesis shows maturation to neutrophils.
Erythroid islands are slightly dispersed.
Megakaryocytes are present in normal numbers & show normal nuclear morphology.
Reticulin is normal.
CD34 is staining <1% of all nucleated cells.
p53 is negative.
CD117 is staining mast cells & proerythroblasts.
CD61 demonstrates occasional small forms.
There is no convincing myelodysplasia.

Can anyone tell me if MDS can come & go?

Has anyone else had conflicting biopsies?

I have been neutropenic for about 4 years with neutrophils going up & down between 0.8 to 1.7.