[Neil Cuadra]

Originally Posted by alawe

why test of my tow sister and my brother is look like together but my result is diferent???

It's random chance. The numbers are HLA (human leukocyte antigen) types, which are genes on chromosome 6. Your parents each have two chromosome 6's, and they each give one to each child.

As a result, your mother has two sets of A, B, and DR numbers (one set on each chromosome 6). Your father has two sets of A, B, and DR numbers too. Each child inherits one of the two sets from their mother and one of the two sets from their father.

Here is one way that you could have ended up with the combination you have.

Suppose your mother has one chromosome 6 with this set of HLA types:

A=1, B=35, DR=12

and her other chromosome 6 has this set:

A=68, B=14, DR=13

Suppose your father has one chromosome 6 with this set of HLA types:

A=68, B=58, DR=14

and his other chromosome 6 has this set:

A=68, B=58, DR=12

Your siblings got the first set from your mother (1,35,12) and the first set from your father (68,58,14), while you got the second set from your mother (68,14,13) and the second set from your father (68,58,12).

Your siblings end up with (1,35,12) and (68,58,14), in other words

A 1/68
B 35/58
Dr 12/14

while you end up with (68,14,13) and (68,58,12), in other words

A 68/68
B 14/58
Dr 13/12

Because your parents' chromosomes have some types in common (A=68 and DR=12) and your father has two similar sets (both with A=68 and B=58), at least in this example, you end up with 3 or 4 types that match your siblings, but not all 6.

This example might not be the real pattern for your parents, since we don't know which combination came from which parent, but the result in any case is a partial match.

As Caregive points out, there's a chance to find a better match in the bone marrow registry. In Iran that's the Iranian Stem Cell Donor Program (ISCDP).