Hi Carrie,
Is his marrow hypocellular (i.e. aplastic anemia like)? People with trisomy 8 usually respond favorably to immune suppressive therapy like ATG. Has he seen Dr. Paquette at UCLA?
Paradoxically, immune suppression also increases the number of trisomy 8 cells. So, if that was part of his treatment in the past, it may explain why trisomy 8 is showing up now.
http://bloodjournal.hematologylibrar...?sso-checked=1
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58 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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