Platelet counts can be very dependant on the degree of hydration. If you are well hydrated the blood is more dilute and the platelet count can appear a little lower whereas if you have had less to drink or the IV fluid has been reduced the blood can be a little more concentrated and the platelet count can seem a little higher. Minor fluctuations can be false. You need to check trends or major unexplainable variations in results.
Prednisone withdrawal definitely causes reduction in neutrophil counts and is a perfectly normal and expected reaction.
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