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Old Tue May 12, 2015, 06:21 PM
PaulS PaulS is offline
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Join Date: Sep 2014
Location: New York
Posts: 247
Hi Bossywife -

Take a breath and don't panic. Your husband is relatively young and fit and that is all good. I don't think the expectancy numbers you are citing are accurate or especially relevant. Sounds like he's been living with MDS for some time.
I do have a couple of concerns/suggestions/questions -
First, understanding his blast percentage is important. They also should have - or should do cytogenetic studies to see if there are any gene mutations - some mutations effect treatment options and prognoses. I am somewhat concerned that it took so long to get you to a hematologist, and it seems to be taking a while to get a full BMB report and treatment plan. Is there a separate oncologist and hematologist? In my experience the hematologist is also the oncologist. Where are you? You mentioned farm and hockey - does that mean rural Canada? Do you have access to an MDS specialist in a big hospital somewhere? There are many great centers in America but I don't know about other places - but if possible - I'd try and see someone with a lot of experience with MDS - at least for a consult.
Vidaza and a related drug Dacogen can be used to put the disease in remission - maybe reduce blasts, mutations and increase blood counts. Its not a cure. Its sometimes used to get the disease into remission in preparation for a stem cell transplant. Based on what you describe, I'd think your husband would be a good candidate for such a procedure - and again you'd want a consult at a really really good hospital where they do such procedures often. A transplant can be rough but does hold out the prospect of a cure.
I'm 56 and had lower risk MDS for three years - probably several years before that. I recently tried Vidaza but it didn't seem to help much and the disease seems to be getting worse - and the doctors are now recommending a transplant. Nobody is saying I only have four months to live - but rather if all goes well 6 months to be skiing again. If you can find good doctors you trust and develop a good treatment/transplant plan then there is every reason to be optimistic - and staying optimistic is very important! Here is a link to a good presentation that describes the disease and treatment options. https://www.pathlms.com/aamdsif/cour...tions/8075AThe website for the foundation where the presentation is, and the foundation in general may have other helpful links and resources
All the best to you and your husband. Paul
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Lower risk MDS diagnosed 2012. Recurring skin nodules treated with prednisone, otherwise watch and wait. HG dropped from 11.5 to 8.7. Kept going down to 5. Vidaza didn't work. BMT from MUD on September 10 2015
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