You are correct, the PNH clone was present from the beginning. At time of dx w/SAA it was only 1%. It remained so until March of '08. It had expanded to 44%, and as of August it is 52%. Do you know of any studies/articles that hypothesize why it expands?
Also I had a BMB done in March. The results were a little worrisome for me. Though my doc is not concerned. It notes "dysplastic changes" "many small megakaryocytes" "blasts not increased above 3%" and "erythroid hyperplasia" and no chromosomal abnormalities. I know that PNH explains the erythroid hyperplasia. It's the dysplastic changes I'm concerned with. What are your thoughts ? I think you're much more educated on this stuff than I am
