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Old Mon Oct 6, 2008, 03:37 PM
Hawaii Bill Hawaii Bill is offline
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Join Date: Jun 2008
Location: Waikele Hawaii
Posts: 100
Clinical protocols

I am facing my second round of AA treatment with ATG. I have been trying to get into a clinical trial at NIH but my counts are not quite severe enough. There is also some question about whether I was treated with h-ATG or r-ATG the first time around, and that might affect which one to give this time.

When I was evaluated by Dr Paquette earlier this year, he mentioned in his letter that my original dosage of ATG was not the standard.

So I am researching protocols and dosages on the web so that I can review them with my hemo before I go in for the next round. I asked NIH, but they said they don't share their protocols.

So far, I found one article that indicates the standard dosages for ATG and Cyclosporin, dated 2005 from Dr Maciejewski:

http://asheducationbook.hematologyli...ull/2005/1/110

Does anyone else have any links or knowledge about this? Also, if one had h-ATG the first round, is r-ATG best the second time? What about vice-versa?

Thanks in advance!
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Male, 56, dx Nov2006 VSAA (BMA:0%). Responded to ATG/CsA/Prednisone/Neupogen Dec 2006, but relapsed in June 2007. Counts are responding to using CsA 200mg bid alone since Jun 2008. Last PRBC tx: Jul 2008.
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