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Hi Skip,
If your marrow is hypocellular, do you know why you were diagnosed with MDS as opposed to AA? Do you have chromosomal mutations? Also, if you do not have a 5q deletion, do you know why your doctor chose to treat you with Revlimid? It is my understanding that Revlimid is primarily indicated for 5q del MDS and multiple myeloma.
I'm just curious if anybody has ever discussed trying ATG/cyclosporine. While it's not usually considered very effective for most types of HYPERcellular MDS, it has had a better track record with the HYPOcellular variety. Of course it would probably depend on the circumstances, but if it were effective, it seems like the potential for full remission would be greater than with Revlimid.
My husband was originally diagnosed with AA (and we still think of it as that), but the diagnosis was changed to hypocellular MDS when they discovered a small trisomy 8 clone. Other than that, it seems like basically the same beast, and it has responded just as well to the immunosuppressant regimen. I'm just wondering if you might fall into a similar category, or is there more going on there that would rule that out?
Take care,
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-Lisa, husband Ken age 60 dx SAA 7/04, dx hypo MDS 1/06 w/finding of trisomy 8; 2 ATGs, partial remission, still using cyclosporine
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