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Hi mola-tecta,
I feel like your mother's metabolism of cyclosporine is completely the opposite of mine. I never saw trough levels of 200, but I guess everyone is different and this is why aplastic anemia is so hard to treat! It's also why you want to see a doctor that treats lots of patients! In her case, cyclosporine measurements are absolutely critical to avoid toxicity. For me, not so much.
I would check all the medications that your mother is taking and make sure that none are interacting with cyclosporine, making it hard for har body to clear it. If there is a drug interaction, then the mg/kg dosage for cyclosporine is irrelevant
Mola-tecta, have you considered having a free consultation at NIH?
Try to stay positive mola-tecta and Matthew. There are signs that things are going in the right direction.
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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