[PKumar]

My wife was diagnosed with AA In Feb 22. She is 76 years old and was treated with ATG , Promacta 75 mg and Tacrolimus 2 gm . Her white cell count came up to 2.5, neutrophils 1500 and hemoglobin to 9.6. She stopped blodd transfusion on May1,22 however she still needs platelets transfusion every 10 days as it drops to a level of 13,000.
In August 22 and Sept 22 doctor increased the dosage of Promacta to 125 mg and tacrolimus to 3 gm a day and also added steroid Danazol 400 mg per day to increase the platelets from low level of 13000 to a higher level of above 20,000 to stop platelet transfusion.

During the last week her hemoglobin has come down to 8.1 and white cell count to 2 after the increased dosage of promacta and addition of Danazol. Her platelets count has not increased much but it is only one week since the start of Danazol.
Has anybody gone thru this type of treatment and experienced this kind of drop in hemoglobin and white cell count. Could it be due to Danazol's initial reaction ? It has been almost 7 months since the original ATG treatment was given.
Can somebody help?