View Single Post
  #2  
Old Wed Aug 19, 2009, 08:40 AM
Birgitta-A Birgitta-A is offline
Member
 
Join Date: Oct 2007
Location: Stockholm, Sweden
Posts: 1,918
Reading BMB reports

Hi Hispit,
You know reading BMB reports is very complicated. There are tables showing the reference range for different cell types and for grading fibrosis but many expressions are only reported in articles with a lot of difficult words.

Here is a link to a book about the bone marrow. You can find results from biopsy from normal adults at page 36-37:
http://books.google.se/books?id=LWez...0cells&f=false

Here is a link where you can find typical bone marrow changes in AA patients:
http://www.pathconsultddx.com/pathCo...675(06)70097-3

CD means Cluster Designation and is a nomenclature system for surface antigens of human leukocytes (white blood cells), macrophages (big white blood cells acting in infection defense), platelets, and other cells, characterized by monoclonal antibodies, allowing these cells to be categorized by lineage.

Grading of myelofibrosis (MF)
Grading Description
MF-0 Scattered linear reticulin with no intersections (cross-overs) corresponding to normal bone marrow
MF-1 Loose network of reticulin with many intersections, especially in perivascular areas (around the blood vessels)
MF-2 Diffuse and dense increase in reticulin with extensive intersections, occasionally with only focal bundles of collagen and/or focal osteosclerosis
MF-3 Diffuse and dense increase in reticulin with extensive intersections with coarse bundles of collagen, often associated with significant osteosclerosis (hard bone).
Kind regards
Birgitta-A
Reply With Quote