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Old Thu Jun 4, 2009, 02:28 PM
sandra sandra is offline
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Join Date: Mar 2007
Posts: 35
Hi B-OK,

We have been exactly in the same situation as your wife. Our son was treated with fluconazole (diflucan) and his CsA level went through the roof. The doctor stopped the CsA for one day completely, and then restarted at a much lower dose. Does your wife's doctor monitor her CsA level? It is a special blood test, where you collect a blood sample right before the administration of the next dose. Usually the doctors like to see that level at 175, higher than 200 you start having renal complications, in our case was increase creatinine and BUN.

You seem to have a science background, are you a researcher?

What worries me about your wife is that if she got candidosis, it is very likely she's neutropenic (ANC - absolute neutrophil count- below 500). The counts that you posted initially looked to me as she was more likely to fall into the severe AA diagnosis, not moderate, as your doctor said. This would warrant an ATG course, not just CsA.

Here is a link to the latest article available online of Dr. Neil Young, who's considered one of the best specialist in US when it comes to AA:

http://bloodjournal.hematologylibrar...ull/108/8/2509

There is a newer version of this article (2008), but is not available online. If you are interested, you can post your e-mail and I can sent you some pdf articles.

Sandra
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