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I didn't know the term "up-regulation" so I had to look it up.
It means that a cell responds to an external factor, like a drug, by increasing the amount of a protein, enzyme, or other component of the cell. Sometimes that's the desired effect of a drug, while in other cases down-regulation (a decrease) is the desired effect.
If I understand the report correctly, it concludes that lenalidomide (Revlimid) up-regulates the gene called SPARC, which suppresses tumors. This gene normally resides at the 5q location that is missing in 5q- syndrome.
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