Thread: Cyclosporine + fluconazole
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Old Tue Jun 2, 2009, 01:50 PM
Hopeful Hopeful is offline
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Join Date: Jan 2009
Location: California, USA
Posts: 766
Hi,

I don't have personal experience with these drug interactions, nor am I a doctor.

However, I found this abstract which talks about how Cyclosporine availability increases significantly with fluconazole, peaking at day 4. It also says that trough levels may not be sensitive enough to pick up the interaction. You may want to show this abstract to her doctor quickly so that you can adjust her Cyclosporine dosage down while on fluconazole.

http://ndt.oxfordjournals.org/cgi/co...ract/14/7/1698

Hope this helps. It's good that you are so observant.
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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