I have been on Agios's drug AG221 for 3 weeks.
http://www.xconomy.com/boston/2014/0...st-early-test/
I just received the BMB report from 2 weeks on the drug. My blasts went from 13% to 4%. They consider this to be enough of a remission for a transplant. ANC, WBC, RBC, HCT all remain low but about the same. Platelets fell from ~100 to 40.
Today I saw both the research doctor and the transplant doctor. They agree that I have an option to go for a transplant in 3 weeks, or continue with the AG221 in hopes that my numbers improve along with my chances of a cure with a SCT. They thought both options were good. They can not speculate whether this drug is a cure or it just causes temporary remission.
Side effects seem mild, uric acid and creatinne are slightly out of range due to eliminating the drug in spite of them having me drink 100 oz. of fluid a day.
What would you do in my shoes?
Ray