Thread: Dacogen
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Old Mon May 23, 2011, 12:50 PM
Birgitta-A Birgitta-A is offline
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Location: Stockholm, Sweden
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IWG criteria for response in MDS

Hi cheri,
You know the International Working Group criteria for response in MDS are quite difficult to obtain – most patients are satisfied if they only get better without fulfilling the criteria.

Here are the criteria for Hematologic Improvements
Red Blood Cells:
Major: Transfusion independence or >2 g/dL increase in hemoglobin
Minor: 50% decrease in transfusion requirements or 1–2 g/dL increase in hemoglobin

Platelets
Major: Platelet transfusion independence, or increase of 30,000/μL if less than 100,000/μL at baseline
Minor: 50% or more increase in platelet count (at least 10,000/μL) if less than 100,000/μL at baseline

Neutrophils
Major: If ANC <1,500/μL, increase of at least 100% or absolute increase of 500/μL, whichever is greater
Minor: If ANC <1,500/μL, increase of at least 100% but absolute increase of <500/μL

http://www.moffitt.org/ccjroot/v11s6/pdf/03.pdf
Kind regards
Birgitta-A
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