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Clinical trials
Hi vikasgoyal,
As far as I understand your father has low risk MDS and only needs txs every 6th week. Most patients with with these symptoms get supportive therapy like txs, EPO and iron chelation drugs like Desferal or Exjade. Then your father is getting Danazol too.
Has his doctor not discussed iron chelation? Some patients get increased HGB when the ferritin level decreases eventually due to less oxidative stress in the bone marrow? The ferritin level should not exceed 1000.
He could try Thalidomide (about 30% respond) or Revlimid (about 60% of patients without chromosome aberrations respond). None of these drugs are low toxic but I have tried both in very low doses with positive effects with low neutrophils (treated with Neupogen) as the only adverse effect.
Kind regards
Birgitta-A
74 yo, dx MDS Interm-1 2006. Supportive therapy until 2010 when I started to take Thalidomide + Prednisone. Transfusion independent during a little more than 2 years. Started Revlimid + Prednisone July 2013.
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