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Old Fri Apr 24, 2009, 06:03 AM
Birgitta-A Birgitta-A is offline
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Join Date: Oct 2007
Location: Stockholm, Sweden
Posts: 1,918
ATG or Revlimid

Hi Skip
It is difficult to choose drugs when you have MDS and we still don't know much about the best treatment for a special patient. Here are links about ATG and Revlimid (Lenalidomide). You know that Vidaza is supposed to be the best treatment for most patients with a little more than 50% responders.

ATG
24% of the patients responded to ATG. 48% of patients responded to ATG plus cyclosporine. Immunosuppressive treatment produced significant improvement in the pancytopenia (low counts in all cell lines) of a substantial proportion of patients with MDS and was associated with improved overall and progression-free survival, especially in younger individuals with lower-risk disease.
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum

Revlimid
A clinical trial evaluating lenalidomide therapy for transfusion-dependent individuals who had low- or intermediate-1–risk MDS but did not have the chromosome 5 abnormality showed a 43% overall rate of improvement with the lenalidomide treatment.
http://rarediseases.about.com/b/2008...s-patients.htm.
Kind regards
Birgitta-A
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