Thread: Neulasta
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Old Mon Sep 22, 2008, 09:45 AM
sandra sandra is offline
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Join Date: Mar 2007
Posts: 35
Hi!

It is difficult to compare. In the japanese study, the minimum period was 3 mo to sometimes yars for non-responders, but they had daily injections with very high doses - 10 micrograms/kg/daily .

http://bloodjournal.hematologylibrar...ract/100/3/786

N. Young study is a lab study, it's done on cell cultures.

http://www.pnas.org/content/103/39/14483.full

In the European study, the dose was 5 micrograms/kg/daily for less than 6 mo.

http://bloodjournal.hematologylibrar...act/109/7/2794

Keep in mind, though, you fall into a different category. First, you had HD Cy, a treatment that ablates the marrow so severely, that I don't think you can survive without G. It is my opinion that even in the case of HD Cy, one should stop G as soon as medically feasible (ANC around 500). Second, later developing to PNH is not considered anymore an "evolution event" per se, as it is the case with evolution to MDS (triosomy 7 or 8). Rather, it is believed that the PNH was there all the time, but the clone was undetectable with available methods.

Sandra
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