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Hi Missy,
If he is only 120 lbs, he is on a very high dosage of cyclosporine. The literature shows that more is not better with cyclosporine. Beyond 6 mg/kg/day, you are just adding toxicity. Is his doctor measuring the 12 hour trough to make sure that he is not at toxic levels? A more saner maximum dosage for him would be about 150mg twice a day (300mg/day total).
It would be good to ask how many AA patients this doctor has treated and why he is recommending cyclosporine alone vs ATG/CyA. It could be because of his age or comorbities, but it would be nice to hear this from the doctor.
It will be great if his next blood test shows the same improvement in his HGB! You need to look for the trend. Some people do respond to cyclosporine alone, but the percentage that do is lower.
Best of luck!
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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